Should Stem Cell Research be Unbound Proposal Example | Topics and Well Written Essays - 4250 words

Should Stem Cell be Unbound - Research Proposal Example Spinal cord injuries and Parkinson's disease are two examples that have been championed by high-profile media personalities (for instance, Christopher Reeve and Michael J. Fox). The Coalition for the Advancement of Medical Research estimates that stem cell research shows promise to develop cures and/or new treatments for 100 million Americans who currently suffer from a wide variety of diseases and disorders. There are several types of issues to consider as we reflect upon stem cell research. ... Many frame the debate about stem cell research around the question of "when life begins," although the issue is not when life begins, but when personhood begins and ends. Human life began millions of years ago when our ancestors reached a stage of evolutionary development that permitted the separate species, Homo sapiens to arise. Human life will end when our species becomes extinct. Stem cell research is a controversial issue in America as, with the present state of technology, the creation of a human embryonic stem cell line requires the destruction of a human embryo. Stem cell debates have motivated and reinvigorated the pro-life movement. There has been a deep and bitter dispute over the conduct of this research; many pro-lifers, for instance, Roman Catholics and conservative Protestants, have opposed this research. According to them, the embryos from which these stem cells are extracted are actually individual entities and have a soul to them. Since the embryos are killed when the stem cells are removed, or stored for long periods of time, long past their viable storage life, pro-lifers view the extraction procedure as murder. In the United States alone, there have been estimates of at least 400,000 such embryos. However, not everyone is opposed to stem cell research. Many groups that even protest it are comfortable with certain forms of cell research. Plent y of experiments and tests have been carried out to determine improved and more efficient ways of saving lives and replacing organs, without having to kill â€Å"pre-embryos.†

The Difference Between Want and Need Essay Example for Free

The Difference Between Want and Need Essay You asked me to define the difference between want and need. And before I could write this essay to you, I had to think about the statement for a while. I had to look up the definition for both of the words want and need. Want technically means to wish for, or to desire. And need means to require, or a necessity, according to the Webster’s New World Dictionary. These two words might mean very different things, but yet they get mistaken for each other almost all the time. I could say that I need that new designer t-shirt that fits me perfectly, but we both know that I don’t need it. I want it. Being a teenager has me believing that I need materialistic things. All teenagers could say the same. I’m going to make a list for you of the things I need, and what I want. What I need: †¢ A roof over my head †¢ Enough food and water to maintain my health †¢ Blood, organs, skin, cells, bones, protein, ect.. What I want: †¢ Fancy foods †¢ Sports car †¢ Name brands †¢ Phone †¢ A big house And the list could go on and on. But hey, does that mean that we should only buy what we absolutely need? Not at all. Since life is meant to be lived, not survived. You can treat yourself to â€Å"wants† along the way to success, but only do so as long as you can afford it. And enjoy those â€Å"wants† for the EXTRAS that they are. â€Å"Wants† are things you without a doubt could live without. But needs, are a different story. Needs are essential, like water and food. Basically things that keep us alive. So here is my attempt to understand the difference between want and need. Thank you for trying to get me ready for life, appreciation is given. Since I’m a kid and I’m still yet to learn my lesson, guess I’ll have to learn the hard way. I hope you liked my writing.

Health Risks of Weight Gain and Obesity

Health Risks of Weight Gain and Obesity This essay will analyse some of the main health risks posed by weight gain and obesity such as the risk of developing chronic heart disease, diabetes and cancer. It will also discuss some of the factors that can impact on wellbeing and the strategies in place nationally to promote healthy living habits. The World Health Organisation (W.H.O), reports that weight gain is a global issue, and reports that â€Å"42 million children under the age of five were overweight or obese in 2013†. Their research found that people who are overweight have a higher risk of heart disease, high cholesterol, high blood pressure, Type 2 diabetes and other chronic diseases such as Chronic Obstructive Pulmonary Disease (COPD), cancer and stroke. To reduce these risks we need to help the body maintain good weight. The British Heart Foundation(BHF) advises people to seek support from a GP or even family and friends who can help to establish long term goals to achieve this. In relation to this, there are two calculations used by health professionals to predict if someone is at increased risk of serious illness: waist circumference and body mass index or BMI (Body Mass Index), calculated by dividing one’s weight (kg) by the square of their height (m). Defining children as overweight is a difficult process since their height and weight changes at the same time, and growth patterns differ between the sexes so separate charts are used for calculations. The National Child Measurement Programme analyses these calculations in preschool children aged 4-6 in the UK and are a part of national measures to tackle obesity. A 2013 survey by Public Health England (PHE) found that obesity prevalence in 4-5 and 10-11 year olds has been increasing. These children would need to lose weight to improve their health and lessen the risk that they will become obese adults. In 2012 The BHF estimated that more than a quarter of adults in England were obese. In its 2012 statistical report, the BHF reported that coronary heart disease was the biggest killer in the UK in 2010. It is a common consequence of being overweight and obese and occurs when fatty material blocks arteries. The BHF advises people to eat healthily, lower alcohol consumption, exercise and avoid smoking to lower the risk. Being overweight can affect the risk of cancer because fat tissues in the body produce hormones that can affect the way cells work. According to Cancer Research UK, obesity is linked to one in twenty cancers in the UK and is also a factor in three of the hardest to treat cancers including: pancreatic, gallbladder and oesophageal. Smoking also increases the risk of developing at least 13 types of cancer including Lung Cancer. Chemicals in cigarettes permanently damage DNA which can cause cancer cells to grow and multiply. Smoking is also a major cause of Strokes and Chronic Obstructive Pulmonary Disease (COPD). People suffering from COPD struggle to breathe in and out due to the long term damage to the tissue around the lungs. The NHS estimates that nearly three million people in the UK are affected by COPD. People can slow the progression of the disease by stopping smoking, eating healthily and exercising. Like Coronary Heart Disease, strokes are linked to high blood pressure, which is often linked to smoking. Strokes occur when the brain’s blood supply is restricted when the arteries become blocked causing blood clots. The NHS advises people to reduce the risk of stroke by eating a healthy diet which can lower cholesterol levels, exercising regularly and cutting down smoking and alcohol consumption. According to Diabetes UK, diabetes affects 3.2 million people in the UK and is associated with high or low glucose and poor blood circulation since it causes arteries to become ‘’furred up’’. Diabetes occurs when there is too much glucose in the blood. Type 1 Diabetes usually appears in childhood and can be controlled by insulin injections. Type 2 Diabetes usually appears in people over 40, and is treated by a combination of eating healthy, exercising and medication. Complications can occur when diabetes is not managed properly since high glucose levels can damage the small blood vessels that supply key organs. Diabetes UK lists complications including: cardiovascular and kidney disease, feet ulcers, eye and nerve problems, and high blood pressure. The NHS reports that High Blood Pressure (Hypertension) , often named the ‘silent killer’, affects about 30% of the English population and if untreated can increase the risk of heart disease and stroke. High Blood pressure can be reduced by altering the lifestyle by stopping smoking, lowering alcohol and caffeine consumption, and lowering weight via healthy eating and exercise. It can also be treated with some medication. Good habits learned in childhood can ensure that key health factors such as eating varied foods as part of a healthy balanced diet and exercising become part of the daily routine. The British Nutrition Foundation recommends teaching children early about the various food groups that make up a nutritionally balanced plate, illustrated via the â€Å"Eat Well Plate†. These food groups and their key benefits are summarised as: -Carbohydrates: starchy foods which should form the base of what we eat and include potatoes, rice, bread, pasta. Some of these foods are available as white or wholegrain and health professionals advise to choose the wholegrain varieties such as brown rice, as they contain more minerals, vitamins and fibre. -Protein can be found in meat, fish and beans and is essential for the body to grow and repair itself. Meat is a main source of B12, a vitamin that cannot come from vegetables. According to the National Institute of Health, B12 deficiency can lead to loss of appetite, memory loss and depression. B12 components can also reduce the risk of heart disease and stroke. Meat can be a source of vitamins, zinc and iron, but also of fat so it is advisable to buy lean meat or poultry. Oily fish such as mackerel and sardines contain essential omega 3 fatty acids that help to fight blockages in the arteries thereby reducing cholesterol and preventing heart disease. -The dairy group comprises milk and dairy products, foods high in fat but which contain calcium, which helps to keep bones strong. Despite being high in calories fats have some beneficial roles such as helping to transport essential vitamins around the body. Fats come in two types. Saturated fat comes mainly from animal products such as meat, dairy and eggs and can increase cholesterol in the body which can lead to heart disease. Unsaturated fat products are found mainly in vegetables and plants such as nuts, olives and avocados and are beneficial to the body and help to lower cholesterol. -Fruit and vegetables help to keep the body healthy as they are low in fat and are high in essential vitamins and minerals such as vitamin C, potassium, as well as fibre which helps to reduce bowel cancer, as well as heart disease and stroke. The Department of Health recommends eating at least five portions of fruit and vegetables a day to reduce these risks and has introduced a free piece of fruit or vegetable portion to every child in primary school aged between 4-6 years under the School Fruit and Vegetable Scheme. Findings in 2014 by the National Diet and Nutrition Survey showed that too many people eat more than the daily recommended amount of sugar. Sugars occur naturally in foods such as fruit and milk, but they are dangerous when added to food and drink such as biscuits, fizzy drinks, sweets and contribute to obesity and tooth decay. To help children develop good eating habits early, parents can engage children in creative activities at home such as cooking demonstrations that can help children to explore and taste new foods,explore new colours and textures which can fuel excitement and interest in food. Children can be involved in the shopping experience,at the supermarket they can select their own fruit and vegetables. Children involved in these activities,or who eat at a table with others are more likely to try different foods which can lower the risk of becoming picky eaters. The WHO recommends that children should undertake at least one hour a day of physical activity. It is therefore important that parents find opportunities to incorporate active play opportunities in a childs daily routine. The NHS advises parents to minimise the amount of time young children under five spend being restrained in a car seat or pram,or watching television. It advises that in order to maintain a healthy BMI,small children under five should be physically active for three hours spread over the day. The guidance includes energetic activities for increased movement such as swimming,using the climbing frame,chasing games involving running e.g. hide and seek. Small children can be encouraged to free play before an evening meal rather than watching television. In addition parents can involve children with physical tasks around the home,for example with cleaning or gardening. Young babies can be involved in light activity at home:such as by encouraging babies to crawl,jump or roll. Parents can let a baby kick on a changing mat before a bath or after being changed. A 2012 Health for England Survey reported that physical activity is important for preschool children as it increases bone and muscle strength,attention,and improves behaviour and achievement. However, childrens play is becoming increasingly restricted due to factors such as parents working later hours, lack of suitable outdoor play space and parents fears about childrens safety on the streets. Some charities such as Change for Life and Play for England campaign to increase awareness of the benefits that play has for children, and campaigns to increase outdoor play spaces for children. They suggest that trips to the local park and adventure playgrounds are great outdoor play opportunities, particularly valuable in a modern, urbanised society. Their Street Play Project for example,campaigns to increase residential-led street play for children particularly in disadvantaged areas. Reducing ill health is one the Governments visions for children and families in the UK, who following the tragic death of Victoria Climbe put together a programme-Every Child Matters to bring together all agencies looking after children in their care to prevent ill treatment. It created legislation to promote childrens mental and physical health by bring together all agencies to improve outcomes for all children in their care. Physical activity is also at the heart of the Early Years Foundation Stage (EYFS) Curriculum,one of the seven areas of achievement intended to help preschool children recognise the importance of physical activity in maintaining a healthy lifestyle by the time the reach the end of the curriculum. Looking after the emotional aspects of life is also an important consideration of wellbeing, sitting side by side with eating healthy and staying physically fit. It is now largely accepted that what children become in their adult lives is to a great extent a product of their experiences in the early stages of their lives (Measuring National Wellbeing 2012). However research carried out by PHE in 2013 found regional differences in physical activity and wellbeing,with higher levels of obesity detected in deprived areas of low income. Issues such as poor quality of housing and material deprivation including toys and food can have a negative effect on a young persons wellbeing. These issues contravene some beneficial principles families should incorporate to promote a harmonious environment in the home where wellbeing can thrive. Two key principles are: -Avoiding conflict within the home as this creates a negative atmosphere -The consistency approach,if followed helps to develop reliability,trust and learning that actions have consequences. In childcare settings it is essential to monitor and evaluate childrens development to ensure that they are not displaying signs of physical, social or emotional difficulties affecting their wellbeing. Equally, education practitioners can also help parents who need support with physical, emotional and economic problems impacting on their wellbeing, by offering access to parenting services such as the Triple P Program (Positive Parenting Programme) which claims that it helps lower parents stress,anger and depression. Courses include individual consultations with trained professionals and group sessions where parents can meet together in an encouraging and non judgemental environment where they can share experiences. In conclusion, the trend in modern society is for people to become less active, in particular children who are leading increasingly sedentary lives. Parents find it challenging to help children meet the recommended minimum of one hour a day of moderate exercise, as parents work increasingly longer hours,and outdoor play spaces are reduced in urbanised environments. Lack of exercise and high carb diets mean that children are more at risk of developing serious health difficulties in the future-obesity,heart disease,weakened bone structure and cancer. It is therefore important for parents to make a change since children who develop an active lifestyle and are introduced to a variety of physical activities are much more likely to continue that healthy lifestyle into adulthood. Governments also need to continue to prevent and promote good health as identified by the Every Child Matters and School Fruit and Vegetable Scheme. Reference List World Health Organisation (2014) Obesity and Overweight,Factsheet No311 http://www.who.int/mediacentre/factsheets/fs311/en/ (accessed 13 November 2014) Townsend N, Wickramasinghe K, Bhatnagar P, Smolina K, Nichols M, Leal J, Luengo-Fernandez R, Rayner M (2012). Coronary heart disease A compendium of health statistics 2012 edition. British Heart Foundation: London. file:///C:/Users/monicasofia/Downloads/2012_CHD_Statistics_Compendium.pdf (Accessed 11 November 2014).Pages accessed: p8,p10 British Heart Foundation,Preventing Heart Disease 2014 http://www.bhf.org.uk/heart-health/prevention.aspx(Accessed 12 November 2014). Public Health England, National Child Measurement Programme Operational Guidance,May 2014. https://www.gov.uk/government/uploads/system/uploads/attachment_data/file/361189/NCMP_operational_guidance_v2_Sept_14.pdf (Accessed 14 November 2014). Cancer Research Uk,Obesity,Body weight and Cancer,2014. http://www.cancerresearchuk.org/cancer-info/healthyliving/obesity-bodyweight-and-cancer/obesity-body-weight-and-cancer Accessed 12th November 2014). Kath Roberts, Nick Cavill, Caroline Hancock and Harry Rutter Public Health England Social and Economic Inequalities in diet and physical activity 2013, p8,9, http://www.noo.org.uk/uploads/doc/vid_19253_Social_and_economic_inequalities_in_diet_and_physical_activity_04.11.13.pdf (Accessed 14 November 2014) NHS ,Chronic Obstructive Pulmonary Diseaese 2014, http://www.nhs.uk/conditions/chronic-obstructive-pulmonary-disease/Pages/Introduction.aspx#close.Smokers (Accessed 13 November 2014). NHS ,Stroke-Prevention,(2014), http://www.nhs.uk/Conditions/Stroke/Pages/Prevention.aspx (Accessed 12 November 2014). NHS,High Blood Pressure,2014 http://www.nhs.uk/conditions/Blood-pressure-(high)/Pages/Introduction.aspx (Accessed 12 November 2014) Diabetes UK ,What is Diabetes, 2014, http://www.diabetes.org.uk/Guide-to-diabetes/What-is-diabetes/ (Accessed 10 November 2014). Diabetes UK,Nerves, Diabetes Complications 2014, http://www.diabetes.org.uk/Guide-to-diabetes/Complications/ (Accessed 12 November 2014) British Nutrition Foundation 2014,www.nutrition.org.uk (accessed 12 Novemebr 2014). National Institute of Health,June,24,2011.Vitamin B12 Factsheethttp://ods.od.nih.gov/factsheets/VitaminB12-Consumer/#h1 (Accessed 12 November 2014) Department of Health,The National Archives,5 a Day http://webarchive.nationalarchives.gov.uk/+/www.dh.gov.uk/en/Publichealth/Healthimprovement/FiveADay/Index.htm (Accessed 12 November 2014). Department of Health,The National Archives School Fruit and Vegetable Scheme 22 march 2010 http://webarchive.nationalarchives.gov.uk/+/www.dh.gov.uk/en/Publichealth/Healthimprovement/FiveADay/FiveADaygeneralinformation/DH_4002149 (Accessed 12 November 2014) Public Health England Reducing Obesity and Improving Diet,Public Health and Young People 14 May 2014 https://www.gov.uk/government/news/new-national-diet-and-nutrition-survey-shows-uk-population-is-eating-too-much-sugar-saturated-fat-and-salt (Accessed 10 November 2014) Kath Roberts, Nick Cavill, Caroline Hancock and Harry Rutter ,Public Health England Social and Economic Inequalities in Diet and Physical Activity 2013 http://www.noo.org.uk/uploads/doc/vid_19253_Social_and_economic_inequalities_in_diet_and_physical_activity_04.11.13.pdf (Accessed 14 November 2014) Health Survey for England Summary of Key Findings 2012 http://www.hscic.gov.uk/catalogue/PUB13218/HSE2012-Sum-bklet.pdf (Accesed 12 november 2014) Every Child Matters,Department of Health -2003 https://www.education.gov.uk/consultations/downloadableDocs/EveryChildMatters.pdf (Accessed 13 November 2014) Play for England 2014 http://www.playengland.org.uk/ (Accessed 14 November 2014) Change 4 Life 2014 http://www.nhs.uk/change4life/Pages/why-change-for-life.aspx (Accessed 14 November 2014) Theodore Joloza, Office for National Statistics,Measuring National Well-being-Children’s Well Being ,2012, http://www.ons.gov.uk/ons/dcp171766_283988.pdf (Accessed 14 November 2012). Triple P Programme http://www.triplep.net/glo-en/home/ (Accessed 13 November 2014)

Rotating Wall Vessel Bioreactor

Rotating Wall Vessel Bioreactor Abstract Recently there are significant amount of research work undergoing about tissue engineering and bioreactor designing. Therefore, there are so may research paper published around the world. It may use embryonic stem cell, mesenchymal stem cell, tissue graft or other animal spaces tissues or cell for development of human and animal medicine treatment. In that case there should be some ethics and laws to control the usage of the tissue or cell in the medical treatment. Some government organizations and private sector by independently or by joining do some research work about the tissue engineering and bioreactor designing. The cardiovascular system is the major disease problem in the human and animal medicine treatment. In recent decade there are cell and tissue engineering and the bioreactor designing involving treating the cardiovascular disease condition. Researchers may try to develop heart valve, wall and blood vessel etc. Hole in the heart is complex congenital heart diseases, in n ew born babies and leading causes of mortality. The treatment of this kind of the cardiovascular disease only performed surgery correction, the very painful after the surgery at tolerate by baby. When correcting the hole, that must have closed properly otherwise it lead to another problem to the young one, but measurement of the diameter of the hole is very difficult and correction also very difficult. In the recent decade there is stem cell therapy and the tissue engineering has rapidly developed. By using stem cell and tissue culture there are so many researches and development of the treatment about cardiovascular system. Myocardial tissue engineering developed the heart tissue by using the stem cells in three-dimensional matrices of biodegradable polymers scaffold is the innovation of the myocardial constructs and cardiovascular treatment. Introduction The heart is the most important organs in the human body. It transports blood to the organs, tissues, and cells of the body. Blood delivers oxygen and nutrients to every cell and removes the carbon dioxide and waste products excreted by those cells. A Holes in the Heart is an opening in the septum between atria or ventricles of heart, this is congenital condition. 8-10/1000 live born babies has congenital defects in the heart. This condition occurred during the babys heart does not develop inside the womb; no specific cause for this condition, but some increase risk of being born. If mother had German measles or toxoplasmosis during pregnancy, or if she has diabetes, or if someone else in her family was born with a heart complaint. A hole in the heart may be noticed in the first few months of life or even before the baby is born, sometimes a hole is not found until a person is much older. This often happens when the hole is between the upper chambers of heart. It may notice person a re feeling a bit short of breath and dont know why. But sometimes there are no complaints at all. Because of the hole, the flow of blood through the heart is abnormal. This makes noises in the heart, so a doctor can find the hole by listening to the heart with a stethoscope. If the doctor hears a murmur, this tells the doctor there could be a hole. If the doctor thinks there is a hole, person will have an echocardiogram ultrasound test of heart. Sometimes the hole isnt found until a person is much older when they notice they are feeling tired and breathless and cant find a reason for it. Some holes are so small that they cause no problem and are left alone. Some holes in small babies may close by themselves: if the cardiologist thinks this is likely, he will not close it immediately, but wait for some time to see if it has closed by itself, by repeating an echo. Other holes must be closed, either because they are already a problem, or because they will cause a problem in the future .   There are three different types: Atrial Septal Defect (ASD): this is a hole in the wall between the atria (interatrial septum). This causes more blood to flow to the lungs and may not have any symptoms; the excess flow can damage the lungs. If the hole is small, and doesnt affect the function of heart, theres no need to fix it. Ventricular Septal Defect (VSD): this is a hole in the interventricular septum or wall between two lower chambers (RV and LV). If its large, can change the mechanics in heart. This makes the heart work harder than it should and can enlarge it. If the hole is small, and doesnt affect the function of heart, theres no need to fix it. Atrioventricular Septal Defect: this is a large hole in the middle of heart between the atria and ventricles. Some people with this condition only have one valve between the atria and ventricles instead of two. This defect can also damage the lungs by allowing too much blood to flow to the lungs. Although this condition is uncommon, t can be found in babies born with Downs syndrome. VSDs are the commonest lesion about 25-30% of all congenital heart defects whereas ASD are about 5-8% of them. Another point to remember is that all of us are born with small ASD. However, VSD is never found in normal heart. The only treatment available  was surgical closure. Though the ultimate outcome was good, these children had to inevitably suffer the pain, scar and long hospital stay. There are two ways to do this. The first way is via an operation called catheterisation. This is when a cardiologist puts a tube into leg that goes up towards heart.   Then put a device through that tube so that it fits into the hole. When its in the right place, the device opens like a little umbrella, and blocks the hole. The device stays inside forever. This is not possible, because of the size, shape or position of the hole. In these more complicated situations, a surgeon will perform an operation where he puts a patch over the hole directly. If holes have between the two pump chambers of the heart that stay open, will need antibiotic treatment at certain times. This might be before having other operations or serious treatment at the dentist.  Most patients who have ASD/VSD corrections go on to lead perfectly normal lives. Person will be followed-up for a short period, but if everythings OK after a year, wont need to worry about it ever again. It also doesnt increase the chances of having any other heart-related issues in the future but should take regular exercise and aim for a healthy diet. After correction of the hole in the heart there are low risk for structural degeneration, thrombo-embolism and endocarditis and growth potential for paediatric patient. From 1970s onwards, a group of cardiologists started thinking differently. They experimented on animals by creating holes in their hearts and then tried closing them without surgery. Gradually they replicated the whole procedure on humans. For the last twenty years, nonsurgical closure or device closure has bee n the normal. Adult life heart muscle cells do not proliferate, if there is damage or injuries happened to the heart, functional tissue try to form the non-functional scar tissue. In 1996, 98 Klug et al. Suggest that development of human Embryonic stem cell derived cardiomyocytes help for therapy of cardiac disease. There are some experiments done by using stem cells. Stem cells are the cell ability for self-renewal and the potential for differentiating into mature cell types. The embryonic stem cells can give rise to almost every mature cell type, while adult stem cells are classified as restricted to differentiation into only few types of mature cells. The mesenchymal stem cell can only differentiate to one specific mature cell type, are referred to as precursor cells. First clinical applications of stem cells for cardiac regeneration comprised cell transplantation trials. These trials were less successful than promising preclinical studies; these efforts initiated intense research activities providing new insight into the mechanisms of tissue growth and differentiation. Cardiac tissue engineering is focused on three different organ subunits: the myocardium, valves, and vessels. These three compounds of the heart can already be replaced by artificial or biological transplant constructs with th eir respective limitations, like assist devices, commercial heart valves, autologous coronary bypasses, etc. When developing the heart tissue must consider produced cardiomyocytes, vascular endothelial cell and the smooth muscles cell. Engineering these tissues must compete with the durability, efficiency and safety of existing substitutes and be affordable at the same time. Tissue engineering is the development of biological substitutes that restore, maintain, or improve tissue function or a whole organ, includes an in vitro. During designing of bioreactor, physiochemical environment maintain is very impotent, that will help to kept high quality of the stem cells and high degree of reproducibility of the cells. But must make sure cell culture has developed under sterile environment and sufficient nutrition and waste product exchange throughout the medium and clean and maintain the medium. After that, design some mechanical and hydrodynamic force to compression or expansion of the developing tissue, like shear stress to the tissue. Then maintain steady flow of media in pulsatile manner and reduce the excessive turbulence in the fluid flow rate. Other than that, must provide the low volume capacity for effective use for growth factors and medium, also select the fabricate material compatible with the heart tissue or stem cell. The bioreactor designing for heart tissue development must determine some specific design and functional requirement. Both biomechanical and biochemical factors affect the growth of t he cell therefore essential to create some control mechanism by stimulate the physiological environment for heart cell growth, like pulsatile forces, pressure, flow rate, compression, expansion, shear stress, frequency, stroke rate and stroke volume. Other than that, when creating heart tissue must consider cardiac flow rate and pressure. When consider the design the bioreactor, there are nutrition, oxygen, carbon dioxide, waste product, pH, temperature and humidity are main important biochemical controls affect the growth of the cell. There than the flow rate, volume, shear stress, pressure, resistance and compliance like biomechanical controls also involved in the cell growth. Therefore, specific bioreactors are need for the growth of the stem cell. Because inside the body, cells are always stimulated by mechanical, electrical and chemical signals, these influencing their behaviour. In fact, biological tissues adapt their structure and composition to surrounding specific and funct ional demands. By putting cells alone or only in contact with materials in culture medium is not enough to obtain a functional tissue. In vivo, the heart valves are subject to a unique combination of mechanical stimuli, including flexure, shear stress, and tension (Vesely and Boughner 1989). In growth of the embryonic stem cells require temperature, partial pressure of oxygen, partial pressure of carbon dioxide, pH, and shear force and biochemical conditions of their micro- and macro-environment. Then try to find homogeneous and constant conditions for micro- and macro-environment for the entire cells population. By uneven cell distribution, lack of nutrition and oxygen and insufficient extracellular matrix production cause some limitation to bioreactor scaffold in stem cell culture. Therefore, get rid of those must make to stem cell onto polymers, which will increase the mechanical strength of the heart tissue construction and develop subsequent tissue formation. To develop a bioreactor to provide cyclic flexural stimulation, to demonstrate the operation of the bioreactor and sterility maintenance and to evaluate the effects of unidirectional flexure on the effective stiffness of bioresorbable polymeric scaffolds which have been used extensively in the tissue engineering of the heart tissue. Therefore, must design the devices for closed controlled environment in which biological and/or biochemical processes are developed maintained pH, temperature, pressure, nutrient supply and waste removal, with high degree of reproducibility of the heart valve. Therefore, bioreactors are particularly crucial for the regeneration of complex 3D tissues. The bioreactor was designed using 3D software. The structural element of the device was machined from polysulfone; chosen for its excellent thermal and chemical stability; and abrasion-resistant acrylic; which provides good optical transparency. Culture medium was Dulbeccos Modified Eagles Medium with 4.5 g/L glucose and L-glutamine supplemented with 10% fetal bovine serum. Antibiotics were excluded to assess the intrinsic ability of the bioreactor to maintain sterility. When developing scaffold use the degradable material and permanent materials as in artificial implants and in use of cells. Then preparing scaffold must test in vitro and in vivo how they hypotheses of scaffold and cell interaction, scaffold effect on tissue growth and 3D environment effect on stem cell differentiation. Scaffold materials consisted of a non-woven mesh of polyglycolic acid(PGA) fibers dip-coated with poly-4-hydroxybutyrate (P4HB), and a non- woven, 50:50 blend, mesh of PGA and poly-L-lactic acid (PLLA) fibers dip-coated with P4HB. The PGA and PGA/PLLa scaffold had an approximate fiber diameter of 0.012-0.015 mm and density of 69mg/ml. Rectangular scaffold sample were cut to size (approximately 257.5x2mm) and dipped briefly into a solution of P4HB in tetrahydrofuran (1% wt/vol), resulting in a P4HB coatin g following solvent evaporation. P4HB is a bioresorbable thermoplastic that allows for scaffold to be moulded into any shape. Scaffold were cold gas sterilized with ethylene oxide prior to use. The use of bioreactors, chambers which provide the flow of nutrient media for the development and culture of heart valves construct, to provide an environment which as closely as possible mimics the natural in vivo conditions. These bioreactors have been designed for pulsatile flow, driven by a pulsatile pump, which leads to the exertion of only a positive pressure. This is not the case in vivo, as during the cardiac cycle the positive pressure exerted by fluid force is slightly counterbalanced by a little vacuum. Stem cells grow in vitro under bioreactor conditions must provide the nutrient and they produced the nitrogen contain waste product, but they sensitive to the nitrogenated waste product. This will be varying with the tissue and that will change the shear stresses effecting on the tissue. The oxygen pressure is maintained at set constant value with calculated volume of solution added every time to the medium. Other way round maintained the carbon dioxide pressure at set cons tant value with calculated volume of waste product removed from the medium. Oxygen is most important nutrients for cells in all aerobic metabolic cycles. It is the limiting nutrient in successful tissue growth in vitro, sufficient amounts of oxygen to the surface of the cells mainly because of the poor solubility of oxygen in culture media. In that case hypo-oxygen or hyper-oxygen stresses will be concern the stem cell culture causes of programmed cell death or apoptosis. Therefore, adjust the stem cell for the anaerobic cell metabolism with low oxygen tension (40 mmHg) and low pH or for aerobic cell metabolism with higher oxygen tension (80mmHg) and high pH. Then living tissue is sensitive to pH changes in the medium, during maintain of the oxygen level must maintain the pH also. Other than that glucose and lactate are providing to cell metabolic process. Therefore, they act as the indicator for cells activity. In the bioreactor environment stem cell proliferates and increased the mass that leads the limitation of the final size of the tissue grow. Other than that, there are spaces to pass oxygen and nutrient throughout the scaffold otherwise this also leads to limitation of the tissue growth. Therefore, bioreactor must design to proper diffusion of oxygen and the nutrient and mass proliferation; cell will survive and proliferate within 150-200 µm distance. Shear stress will affect the tissue culture growth, most of the stem cell responds to it. They are proliferating according the orientation of the flow direction. In that case stem cell can aggregates by using higher shear stress that can be used for tissue function and viability. If design the rotating bioreactor that can decrease the shear stress and avoids the contact between the cells and the wall of the bioreactor, chamber must permanently rotate with one direction and control to forming uniformed growth of the tissue. But if design the non-rotating bioreactor then must create the specific mechanical stress applied on the cell culture, by perfusion solution can passed through the cell tissues by flow through the culture chamber. Some experiments were demonstrated that the shears stress 0.1 dyn/cm2 was ideal for stem cell to growth. If that exceeds the shears stress 1 dyn/cm2 were damaged the cells and the shears 0.01 dyn/cm2 were insufficient to promote the growth.   Bioreactors have developed functional heart tissue in vitro environment over specific biochemical and physical signals known to regulate cell differentiation, by improving the formation of the heart tissue by proving uniformed mixing pattern, transported the nutrient to enhance the cell growth and hydrodynamic or mechanical stimulation for stem cell to develop. Simple static flasks or a magnetically stirred flask is not suitable environment for 3-dimensional heart tissue scaffolds to develop. To develop the lowest possible homogeneous cell number for heart tissue, must grow the cell with uniform and efficient of porous scaffolds. When compare the cells seeding into mixed petri dishes yield with the static loading of the cell into the scaffolds has thicker constructs and more spatially uniformed distribution of cells. By seeding in rotating vessels or mixed flask must maintain a uniformed suspension of isolated cells and provide a relative velocity between cells and the scaffold durin g seeding. Dynamic seeding using mixed flasks will show to achieve seeding efficiencies approaching 100% but led to cell densities higher at the scaffold periphery. Therefore, when design bioreactor; must provide the scaffold perfusion with a cell suspension in alternate directions, which lead to the more homogenous seeding on a variety of scaffold with potential yield. Once the cells are associated with the scaffold, cell-polymer constructs can be cultured in bioreactors applying specific regimes of fluid flow. Selecting rotation wall vessels bioreactor The bioreactors are used for proliferation of cells on a small or large scale, to generate 3D tissue constructs, a certain process must occur. That case the cells are proliferated in a bioreactor to provide the quantity of cells needed. The cell loses their specialized characteristics during the process of proliferation is the problem. Therefore, microcarrier culture used for improves cell expansion significantly and that mixed the bioreactor system well. After the cell proliferation they must associate with enhanced heart tissue formation. In above process cells must receive proper nutrition and a stable environment. There for controlled the temperature, optimum pH, sufficient substrate, water, salts, vitamins, and oxygen. The Rotating-wall vessel culture is the best bioreactor for culturing constructs stained intensely, and homogeneously for scaffold for their cross-sectional area. Inside the bioreactor a dynamic flow generated by a rotating fluid environment is an alternative and efficient way to reduce diffusion limitations of nutrients and wastes. The rotation produced the low level of the shear stress to the cells, creating mechanical stimulation. Other than that, there are other mechanical forces that affect the cells during growth, like mechanical compression, hydrodynamic pressure, and fluid flow. They will affect the magnitude, frequency, and duty of the bioreactor cycle.   To control the free-falling state adjusted the rotation speed, it protects the fragile tissue by decreasing the shear stress and avoiding the contact between cells and the walls of the bioreactor. During 1990s NASA scientist did some research about the microgravity involved in to the cell tissue of the mammals. They used the closed tubular cylinder forms the systems cell culture chamber, which filled with a liquid medium where the cell grows on micron-size beads. The chamber has rotated along the horizontal axis; in that case they allowed the cell to develop in an environment like the free fall of microgravity. They supply oxygen and nutrition through a porous wall in the chamber, as same way they removed the waste product and the carbon dioxide. The rotating wall vessel bioreactor is providing the conditions of weightlessness for microbes by growing them inside of a slowly rotating liquid-filled chamber. The process of the rotation liquid has counteracted with slow sedimentation of the cell by creating a constant free fall of the cells through the culture medium. While rotation cell gets a slight sheer stress from liquid, lead to avoid the flattened on the bottom of the container. The scientist used the clear shell for allowed to check growth and cylindrical filter holds on the centre for supply the oxygen and nutrition and removed the carbon dioxide and waste products. And, they insure the fluid rotation without shear stress would leads to destroy the cells. They noticed rotation vessels did not cancelled the gravity, but that maintain the cells in continual free fall environment inside the shell.   Bioreactors for the application of physical forces to engineered cartilage tissues. In the rotating wall vessel system (A), the rotational speed is adjusted so that the drag force of the medium (Fd) is balanced by the centrifugal (Fc) and gravitational (Fg) forces. The constructs are thus maintained in a tumble-slide regime and the resulting dynamic laminar flow enhances the production and accumulation of cartilaginous extracellular matrix. Specific culture chambers (B) have been developed for the application of direct deformation to engineered constructs. Chambers include wells to allocate tissue constructs (I), a magnetic bar for medium stirring (II), an inlet/outlet port for medium change (III), a cover lid to maintain sterility (IV), and micrometer screws to accurately establish the contact position between the plungers and each specimen (V). The cell seeding is effects of shaking speed and initial cell concentration in suspension on cell culture medium, therefore cell seeding must do in efficiency. In that case initial seeding density and cell distribution within the scaffolds must understand. Initially cell concentration is low, in that time seeding efficiency and initial density will decreased with increasing shaking speed. But high initial cell concentration that will reverse the result. All the different cell concentration uniformity of the cell distribution decreased with increased shaking speed. But under the same shaking intensity were observed with on significant differences in uniformity between cells with different initial concentration. In vitro the tissue engineering of heart tissue structures is to develop combined cell seeding and perfusion system. Cell seeding is consisting of whole system, that incorporated into the perfusion system and air-driven respirator pump connected to the bioreactor. Therefore, ce ll culture medium is closed-loop system that will continuously circulate. Therefore, scientist developed a cell seeding device for static and dynamic seeding of vascular cells onto a polymeric vascular scaffold and a closed-loop perfuse bioreactor for long term vascular conditioning. By using cell seeding chamber can be easily connected to the bioreactor, which have combines continuous pulsatile perfusion and mechanical stimulation to the tissue -engineered conduct. In that scientist adjust the stroke volume, the stroke rate, and inspiration/ expiration time of the ventilator allow various pulstile flows and different levels of pressure. Discussion When selecting of the scaffold consider the biocompatibility, reproducibility, biodegradability, ability to be processed to complex shapes, ability to support cell growth and proliferation and mechanical properties of materials. Other than that, scaffolds must have similar electrical and functional activity with create systolic force. The limited availability of the incubator space; the place where the multiple bioreactors place, in this space multiple bioreactors must be places. Development of the stem cell is temperature depended process, any cells grow at body temperature in optimal level therefore temperature must maintain in that level as possible. The bioreactor design must set the temperature parameter to monitor the temperature. If inside temperature changes by increased or decreased then that must alarm on, then it can adjust manually. Sterility is very important throughout the development of the heart tissue. We used flask and glass vessels with threaded fitting, which is cheap and proved to maintain perfect sterility. To reduce the risk of contamination, make sure all connections before sterilisation and sterilize bottles with correction solutions connected to the vessel, by using either alcohol or stem. The tubing can be placed into the pump head easily after the sterilization. Because contamination of the medium lead to the growth of the heart tissue. Therefore, bioreactor must develop as a semi-closed system. Maintain the small cell culture medium all the time, easy replace the balance amount of the cell culture medium for requirement created by cell seeded as soon as possible. If require in addition to that easy seeding of the additional cells. Maintain the oxygen level in the medium is very essential; therefore, reassure the amount of the oxygen in the medium is enough for the development of the stem cells. When we maintain the pH level in the medium that passively adjust oxygen level in the medium, by enrich the medium with CO2 level up to 5%. The biocompatible substances must use when the designing process of the bioreactor, those substance will not kill the stem cell during the tissue growth. There are many analytic parameters, those must monitor regularly with some sensory methods to alarm if there are any changes occur in the media and correct it manually. Any design bioreactor can have ability to experiment several times with longer period. If there are any alternations, like chan ge the cell culture medium with ingredients needed or changer scaffold materials change those and can perform the process easily. By using roller pump can sucks the cell culture medium from the bioreactor, which leads to stress of the scaffold. This help to stem cell growth towards the heart tissue. This bioreactor must use inside the hospital, for treat each of the hole in the heart patient therefore this must produce low cost heart tissue for the patient. Other than that, there should be very low laboratory involvement and convince for patient and the surgeon. When using this kind of tissue engineering think some social highlight that affect the both quality and quantity of the life. Some religious background this technology is some bad for the life, ethical concern there are some extent to do those kinds of experiment. But medical point of view this is the good solution for treatment of the patient without suffering. In that case be careful of handling with stem cell and other, that will lead to caused critical threat to handler. Conclusions The developed bioreactor has set sterility at least week, with working tool for conducting experiments regarding heart tissue growth. The growth of the heart tissue helps to develop entire heart, which can helpful to many heart diseases. Nutrition concentration must keep in mind when performing the bioreactor process. When the time of the replacing the medium nutrition concentration must maintain, also try to minimize the number of time replacement the medium. Acknowledgment I would like to thank Professor Alicia El Haj, Dr. Nicholas R. Forsyth and Dr. Ying Yang for their support and guidance in completing this study. I would like to special thank Dr. Sun Tao for his support and guidance in completing this study.

For Esme- With Love and Squalor Essay -- J.D. Salinger Literature Essa

For Esme- With Love and Squalor 1) In â€Å"For Esme- With Love and Squalor,† J.D. Salinger addresses a part of every person’s life. Everyone experiences periods in their life when they question the world and what is happening around them. Most people probably do not experience it quite as dramatic as the writer of the story, Sergeant X, does. He finds himself in the middle of the pure madness of war, and is having a hard time coping with the realities of the situation. Eventually, people find their way of dealing with these moments. Sergeant X relies on his memories of Esme to help him. The theme of the story is that the innocence of youth can serve as a healing power in times when the world seems to be falling apart. 2) â€Å"For Esme-With Love and Squalor† is essentially a story within a story; this is important to the theme of the story because the writer attempts to remove himself from the story (in first person narration) for the purpose of examination (in third person). This use of point of view makes the reader wonder what is â€Å"real† and what the author (inside the story) is â€Å"making-up.† This sounds strange because the whole story is fictitious, but Salinger makes us contemplate this and it adds to the effect of the story. 3) The first part of the story is told from first person narration. We are told the reason for writing is â€Å"†¦to edify, to instruct†¦Ã¢â‚¬  the man that Esme is about to marry. Throughout the first half of the story we are given the impression that the writer is admiring Esme for her youth and innocence, or love as the title suggests. Before the change to third person narration, we are told that this is going to be the squalid or repulsive part of the story. The writer then â€Å"disguis... ...d period of his life. 8) Innocence in a world of death, tyranny, and oppression seems ridiculous. The world has a way of destroying and making one numb to the ideals and values we once held in our youth. In Stephen Crane’s novel â€Å"The Red Badge of Courage,† we are told a story of a young man’s journey into manhood in the backdrop of the Civil War. Henry, as did Sergeant X, had a difficult time coming to terms with the realities of war. Sergeant X dwelled upon his experiences and allowed them to haunt him. We are told at the end of â€Å"The Red Badge of Courage† that Henry is able to â€Å"†¦rid himself of the red sickness of battle.† Crane writes that he turns â€Å"†¦ with a lover’s thirst to images of tranquil skies, fresh meadows, (and) cool brooks.† In â€Å"For Esme- With Love and Squalor,† Sergeant X turns to the tranquil memories of innocence triggered by Esme.

Rock Music :: essays research papers

Rock is a popular form of music that has evolved over the past couple of decades starting in the 1950s until present day. Rock music has been know to be used as a form of expression over the years. Despite its sometimes negative and defiant lyrics, rock is a form of art that allows one to release his/her feelings through singing in an expressive tone. I personally don’t see problem with people expressing their emotions and that is in part why I dont’t agree with Richard Brookhiser in stating that,‘‘Rock is a popular culture that aims downward in terms of class and age instead of aiming up. Rather than aspiring, it desire.†   Ã‚  Ã‚  Ã‚  Ã‚  I feel that everyone should have a way of expressing themselves in any way or art form that they feel is necessary. Rock music is just a form of letting people let out their anger and agression and not hold it inside. I’d rather see our society release our troubles in a musical form rather than in a violent one. There are much more things to worry about than to stress over rock music bringing culture down.   Ã‚  Ã‚  Ã‚  Ã‚  In this day and age I strongly believe that Rock music helps more than it harms those who listen to it. Unlike Mr. Brookhiser’s views I see rock as being an outlet rather than a downfall. Rock music should be taken for nothing more than just a form of music. Whether its R&B, rap, jazz or rock music is just music and it shouldn’t be held accountable for peoples wrong doings. Rock, just like other types of music should be given the same freedoms and rights to be played and heard by those who want to listen.   Ã‚  Ã‚  Ã‚  Ã‚  People who have the same views as Mr. Brookhiser would be best to just not listen to Rock music at all and not comment on it. To say rock is responsible for aiming downward in class and age is putting too much responsibility on music rather than the people. We all have brains and the ability to distinguish from right and wrong. I understand that some of the lyrics that are said in rock music may be offensive but that should not make it be blamed for bringing down the society.   Ã‚  Ã‚  Ã‚  Ã‚  If you want to sit down and discuss whats bringing down the society, issues such as drugs and single parent families would be more relavent.

Barriers Of Implementing Technology In Education

Over the past fifty years or so, teachers and parents have read and heard forecasts of an impending educational revolution each time a new technological innovation arrived on the scene. Fifty years ago, radio broadcasting was suppose to revolutionize education. Soon thereafter, teaching machines were predicted to bring sweeping changes.Next, television was touted as the medium that would solve problems facing education. Now, the computer is being hailed as the next technological innovation to have a major impact on the educational process.Modern education, in fact, has sustained a long-term interest in the use of educational technology as a means to design more efficient learning opportunities for students. There are tools on how to use the new electronic technologies and this includes: skills software; computer graphics; word processors; telecommunications; simulations; multimedia/hypermedia; virtual reality and distributed learning.. In a field with such a wide range of powerful an d complex tools, experts cannot help but disagree about what teachers need to know and even where they should begin.Not long ago, many experts advised teachers who wanted to become capable computer users learn to write computer programs in languages such as FORTRAN and BASIC. To become computer literate, many assumed that teachers needed to know enough about the technical workings of computers to follow. Few people today believe that teachers need this much technical skill, but textbooks still provide wide varieties of information for beginning technology users. The following steps are needed to take by the beginning technology users: †¢ Develop a philosophy.Teachers must observe where current resources and types of applications fit in the history of the field. Then they must begin developing personal perspectives on the current and future role of technology in education and in their own classrooms. †¢ Purchase products. Teachers must become informed, knowledgeable consume rs of computer products and select wisely among available alternatives. †¢ Identify the problems. Teachers must be able to troubleshoot computer systems they use frequently in order to discriminate between problems they can correct and those that will require outside help.†¢ Speak the language. Sufficient understanding of the terms and concepts related to technology allows users to exchange information with other teachers and experts and to ask and answer questions to expand their knowledge. †¢ See where technology fits in education. In perhaps the most important- and the most difficult- challenge, teachers must identify specific school activities where technology can help to improve existing conditions or to create important educational opportunities that did not exist without it. As part of this process, teachers decide what they need to make these changes occur.This process of determining where and how technology fits is known among users of educational technology as integration. Successful integration requires a connection between how people learn and how teachers employ technology to assist and enhance this learning. DISCUSSION Computer networks offer a significant opportunity for improving the educational climate, especially in situation calling for teaching at a distance in settings which are either primarily educational or primarily business oriented. Computer-based education networks are characterized by a large-scale central computer connected by a communication link to remote terminals.Students work at the remote terminals either individually or in groups. The major advantage of computer-based systems to the student is the potential for individualizing instruction.. Student progress can be continuously evaluated and the student can be assigned to appropriate learning activities. Individualization of instruction is possible because of the one-to-one interaction between the educational system and the student. As far as the student is co ncerned, this is a confidential interaction between himself or herself and the system.The fact that the student is one of many persons using the system at the same time, and the fact that a record is often made of the students’ progress, do not seem to detract from the feeling of individuality and confidentiality on the part of the student. The significant problem for many students in using computer-based system, especially adults, is the typing ability required for the use of the system. The need for typing can be minimized by the use of programming techniques that limit the complexity of responses. System malfunctions are another disadvantage of computing networks and are very frustrating to the individual student.Malfunctions can occur either in the computing itself or in the communication links between the computer and the terminal. While the geographic and time-scheduling of computer-based systems can be an advantage, it can also be a limitation. The terminals themselves and communication links are expensive. At present they cannot be universally located throughout the world. The distribution of other educational materials, such as books, can be accomplished with considerably more ease. Information technology (IT) can be a very effective distance learning medium.The IT package consisted of word processing, spreadsheet and communications software (via Telecom Gold) and a personal computer. IT is an interesting teacher. It can make learning easier and more attractive; for example, a resource for learning about animals could include written information about their habitat, and pictures of it. There could be video clips showing the animal running, accompanied by animated diagrams of the operation of their skeletal structure and muscles. IT is also a patient and responsive teacher. Software does not tire of waiting for a response.Computer Aided Learning software can give pupils immediate feedback. Pupils are rewarded as they make incremental progress. T his can be particularly helpful where pupils have learning difficulties. Rewards can be structured so that pupils are motivated to learn. IT is pupil centered. Unlike traditional didactic teching, strategies for teaching IT will emphasize pupil centered, resource-based learning. This helps IT teachers with the particularly exaggerated problems they have in planning and controlling continuity, progression, differentiation, and breadth and depth of learning.After citing some of the benefits derived from using IT, what therefore, has inhibited a greater use of IT in management education? One reason may be a paucity of good quality educational material for use with computers. Another reason may be a lack of incentive or a resistance to change. Economic reason is also a possibility. Until very recently the use of IT as an instrument for individual learning has been prohibitively expensive. However, the reduced purchase price of the microcomputer has helped lower that barrier. Many teache rs are busy with their daily routines and can find any excuse when asked to add something new.â€Å"Why change what is working? † Many teachers find that it is easier to maintain the status quo: staying with what has been comfortable. Some teachers are afraid of taking any risk and exposing themselves as lacking skills, especially in front of their students. According to Rick Maurer, this fear of change can be categorized into three levels of resistance. Level One: â€Å"Resistance to any use of technology. † These teachers do not understand what the administration is trying to accomplish, or doubt if the school realizes how much technology will cost in time or money.They have their own ideas about what the school should do-they like the status quo, and believe the timing is wrong. Their main concern may just be fear of letting others know what they don't know. Level Two: â€Å"Deeper than the use of technology. † These teachers believe the administration has ma de promises before which they did not keep. They are afraid that technology use is really the start of something deeper and fear if they do not use technology, they will no longer be included as â€Å"in. † Actually, many of these teachers may be worn out by taking on so many changes all at once and may not be completely opposed to using technology.Level Three: â€Å"Deeply embedded resistance. † These teachers may have developed deeply entrenched distrust over many years. They fight anything the administration is supporting because values differ from what teachers want and what administration is proposing. Teachers need a great deal of motivation when it comes to implementing technology in the classroom (Gahala, 2001). There are many obstacles to overcome. Technology can be very intimidating for many teachers â€Å"because introducing technology almost always requires new learning† (Dyrli & Kinnaman, 1994).â€Å"Teachers may lack the time and the motivation to learn technology skills . The integration of technology into the curriculum will not succeed without giving teachers ample time to practice, explore, conceptualize, and collaborate† (Gahala, 2001). This can be done by inviting them to join the school technology planning committee. â€Å"Solicit teachers' participation on the technology planning committee and explain why their participation is important† (Conner, 2002). Another barrier to consider is the cost of technology to be implemented.Computer-based systems are more expensive to set-up. Hardware and softwares must be purchased and staff must be re-trained or recruited. Some disturbance and expense can be expected due to the need for the installation of additional electrical power circuits and computer network cabling and redecoration in parts of the school. Besides the high initial cost, the primary problem with investing in technology is the changing pattern of technology usage along with revisions in the associa ted definition of â€Å"adequate resources†.Maintenance and security for existing resources also became important cost issues. In the 1980’s and 1990’s, new directions in technology use replaced the emphasis on microcomputers with the trend toward multimedia and integrated learning systems. Schools now face a dual challenge that seems likely to remain the only constant amid changing educational technology. Monetary costs associated with the implementation of computer-based technology system includes : 1) Capital cost of computer and network hardware and software; 2) Installation cost, including classroom and laboratory renovation.; 3) Hardware and software upgrades; 4) Support personnel for hardware and software installation, repair, and maintenance; 5) Support personnel and facilities for training and support of users (instructors and students). Obsolete computers are replaced with more powerful computers, which include more sophisticated peripherals and networ k connections. These computers, software, and the associated infrastructure require a greater level of training to use and maintain. Public school systems in the U. S. are currently spending $4,100,000,000 on hardware and software [8].A detailed study of K-12 education estimates that a reasonable target spending for technology should be approximately $300/student, compared to $70/student now being spent [9]. A 1996 forecast predicts spending on educational technology by K-12 and higher education to rise from $6Ãâ€"109 to $14Ãâ€"109 by the year 2000 [10]. As a specific example in higher education, Virginia Tech, which has 25,000 total students, is spending $10-million over four years in an Instructional Development Initiative for classroom and faculty infrastructure.Computer projection equipment is being installed in classrooms, and approximately 1500 faculty members are receiving information technology training and a computer. Once all faculty members complete the course, another 4-year cycle will begin. The dollar amount of this initiative does not include money spent by individual colleges, departments, and research groups for information technology for educational use. Oberlin quotes a total expenditure of $40-million on information technology for a Research-I university of 25,000 students [11].This figure translates to $1,600 per student per year, and does not include the money spent by individual students who can afford their own personal computers, peripherals, and software. Whether purchased with government support, tuition, student fees, or personal funds, the use of information technology is increasing the cost of education. Moreover, other problems may arise during the implementation of technology and these include the following: 1) Methods of working are distorted to fit the requirements of the software used.If the software is not sufficiently flexible so that it can be changed to support current or proposed methods of working then these may have to be adjusted to match the requirements of the software. 2) Bringing new IT-based systems into use can be time-consuming, as it is prudent to continue with both the old system and the new system until it is clear that the new system is working effectively. 3) Software may not do what is required of it. This may happen when the software does not work as it should or because new demands are made for additional facilities that the software is not designed to supply.CONCLUSION/RECOMMENDATION: Nowadays, technology is rapidly moving and we cannot help but to cope with the advancement. It is true that using technology in education is very expensive and time consuming but it was worth the cost. Unfortunately, lack of global long-range planning often amounts to wasted efforts and excessive costs. For an innovation to be successful, teachers need to learn new skills and they may need to unlearn beliefs about students or instruction that have dominated their professional careers (Darling, Ham mond & McLaughlin, 1996).Thus teacher professional development is at the heart of sustaining an innovation. Student support and enthusiasm for the local innovation also played an important role in motivating teachers to continue to carry out and improve the innovation. Teachers want to do what is best for students to enhance their learning. If they believe that students are benefiting from a particular innovation, they in turn will be willing to devote additional time and effort required to maximize the advantage brought on by the innovation.Likewise, educators must resolve many complex issues in order to apply technology solutions to educational problems. They must address many concerns before and during implementation to ensure that technology will have the desired effects on students and schools. These concerns range from funding to selection and placement of technology resources. The author believes that regardless of the downfall of technology, computer-based system of educatio n must go on to continuously improve learning. REFERENCES: 1. Conner, D. (2002, April 12). Technology planning: Closing the communications gap Education World.Retrieved March 19, 2004, from http://www. educationworld. com/a_tech/tech152. shtml 2. Crawford, R. (1997). Managing information technology. London: Roulledge. pp. 131-135. 3. Dyrli, O. E. , and Kinnaman, D. E. (1994, January). Gaining access to technology: First step in making a difference for your students. Technology and Learning, pp 16-50. 4. Crawford, R. (1997). Managing information technology. London: Roulledge. pp. 131-135. 5. Gahala, J. (2001, October). Critical issue: Promoting technology use in schools. Retrieved March 29, 2004, from http://www. ncrel.org/sdrs/areas/issues/methods/technlgy/te200. htm 6. Maurer, Rick. (1995) Beyond the Wall of Resistance: Unconventional Strategies that Build Support for Change. Bard & Stephen. 7. Norton, P. & Sprague,D. (2001). Technology for teaching. USA: Allyn & Bacon. pp. 23-30. 8. Data from a Quality Education Data (QED) report(1996), quoted in J. Chem. Ed. 73, A248. 9. Glennan, T. K. ; Melmed. (1996) A. Fostering the Use of Educational Technology: Elements of a National Strategy; RAND: Santa Monica, CA. http://www. rand. org/publications/MR/MR682/contents. html 10. CCA Consulting Inc.(1996) quoted from News, Resources, and Trends, June 28, 1996, SyllabusWeb, Syllabus Press: Sunnyvale, CA. http://www. syllabus. com/ntr06_28_96. html. 11. Oberlin, J. L. (1996) â€Å"The Financial Mythology of Information Technology: The New Economics,† CAUSE/EFFECT , 19(1) issue of Spring 1996, 21; http://cause-www. colorado. edu/information-resources/ir-library/abstracts/cem9616. html 12. Darling-Hamilton, L. & McLaughlin, M. W. (1996). Policies that support professional development in an era of reform. In M. W. McLaughlin & I. Oberman (eds. )Teacher learning: New policies,new practices. NewYork: Teachers College Press.